Inhalation Exposure

19 Results
Updating the Biologically Based Dose-Response Model for the Nasal Carcinogenicity of Inhaled Formaldehyde in the F344 Rat

Authors: Rory B. Conolly, Jeffry Schroeter, Julia S. Kimbell, Harvey Clewell, Melvin E. Andersen, P. Robinan Gentry
The authors describe an updated biologically based dose-response (BBDR) model that addresses uncertainties through refined dosim...

ACC Formaldehyde Brochure: Compliance With PPE Requirements Is Required by OSHA

The Occupational Safety and Health Administration (OSHA) requires that employers protect their employees from workplace hazards. Personal Protective Equipment (PPE) is integral to workplace health and safety in the formaldehyde industry and is req...

Using mechanistic information to support evidence integration and synthesis: a case study with inhaled formaldehyde and leukemia.

Authors: Gentry, Robinan, Chad M. Thompson, Allison Franzen, Joshua Salley, Richard Albertini, Kun Lu, and Tracy Greene.
This framework, the available evidence relevant to evaluating the postulated mode of actions (MOAs) for leukemia following ...

Considerations for refining the risk assessment process for formaldehyde: Results from an interdisciplinary workshop.

Authors: Andersen, Melvin E., P. Robinan Gentry, James A. Swenberg, Kenneth A. Mundt, Kimberly W. White, Chad Thompson, James Bus et al.
The paper summarizes a 2017 workshop held in order to identify relevant approaches and methods for improvin...

Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA–protein cross-links by liquid chromatography–tandem mass spectrometry.

Authors: Leng, Jiapeng, Chih-Wei Liu, Hadley J. Hartwell, Rui Yu, Yongquan Lai, Wanda M. Bodnar, Kun Lu, and James A. Swenberg.
In this study, both exogenous and endogenous DNA mono-adduct (N2-HOMe-dG) and DNA–protein crosslinks (dG-Me-Cys) wer...

Commentary on New Formaldehyde Studies in Trp53 Haploinsufficient Mice: Further Support for Nonlinear Risks From Inhaled Formaldehyde.

Author: Thompson, Chad. (2018)
The article discusses the relevance of a 2017 final report by the U. S. National Toxicology Program (NTP) that explored the potential involvement of p53 mutation in formaldehyde-induced nasal tumors and lymphohema...

Indoor Air Quality and Asthma: Has Unrecognized Exposure to Acrolein Confounded Results of Previous Studies?

Authors: Golden, Robert and Holm, Stewart
The evaluation illustrated that there is no evidence that indicates increased sensitivity to sensory irritation to formaldehyde in people often regarded as susceptible such as asthmatics. Suggest that p...

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment.

Authors: Gunnar Damgård Nielsen,corresponding author Søren Thor Larsen, and Peder Wolkoff.
Provides a summary of new key studies conducted since 2013, which were evaluated and compared to the WHO guideline. The authors concluded the overall cre...