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Cancer Relationship Plausibility

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Updating the Biologically Based Dose-Response Model for the Nasal Carcinogenicity of Inhaled Formaldehyde in the F344 Rat
Updating the Biologically Based Dose-Response Model for the Nasal Carcinogenicity of Inhaled Formaldehyde in the F344 Rat

Authors: Rory B. Conolly, Jeffry Schroeter, Julia S. Kimbell, Harvey Clewell, Melvin E. Andersen, P. Robinan Gentry
The authors describe an updated biologically based dose-response (BBDR) model that addresses uncertainties through refined dosim...

Cancer Relationship Plausibility Dose Response Threshold Inhalation Exposure Formaldehyde
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa
Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat nasal mucosa

Authors: Rory B. Conolly, Jerry L. Campbell, Harvey J. Clewell, Jeffry Schroeter, Julia S. Kimbell, P. Robinan Gentry
In this work, the authors used computational fluid dynamics (CFD) modeling to predict flux of inhaled (exogenous) formaldehyde...

Cancer Relationship Plausibility Dose Response Threshold Inhalation Exposure Formaldehyde
A Review of Stable Isotope Labeling and Mass Spectrometry Methods to Distinguish Exogenous from Endogenous DNA Adducts and Improve Dose-Response Assessments for Chemicals with both Exogenous and Endogenous Exposures.
A Review of Stable Isotope Labeling and Mass Spectrometry Methods to Distinguish Exogenous from Endogenous DNA Adducts and Improve Dose-Response Assessments for Chemicals with both Exogenous and Endogenous Exposures.

Authors: Kun Lu, Yun-Chung Hsiao, Chih-Wei Liu, Rita Schoeny, Robinan Gentry, and Thomas B. Starr
Some chemical carcinogens can produce DNA adducts and DNA adducts have been used as biomarkers of exposure. However, DNA adducts of various types ...

Cancer Relationship Plausibility Formaldehyde
The Evolving Epidemiology of Nasopharyngeal Carcinoma. Cancer Epidemiol Biomarkers.
The Evolving Epidemiology of Nasopharyngeal Carcinoma. Cancer Epidemiol Biomarkers.

Authors: Ellen T. Chang, Weimin Ye, Yi-Xin Zeng and Hans-Olov Adami.
Findings from this case–control study provide new insight into the epidemiology of NPC. Recent findings from other studies include a protective association with infectious mon...

Cancer Relationship Plausibility Formaldehyde
The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens.
The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens.

Authors: Mundt, K.A., Dell, L.D., Boffetta, P. et al.
The authors systematically evaluated the epidemiological literature on the four chemical agents (1,3-butadiene, formaldehyde, benzene, and tobacco smoking, excluding pharmaceutical, microbia...

Cancer Relationship Plausibility Formaldehyde
An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors
An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors

Authors: Thompson, C. M., Gentry, R., Fitch, S., Lu, K., & Clewell, H. J.
In this evaluation, the authors review and update the mode of action (MOA) framework for nasal tumors, with particular emphasis on the studies published since 2006. In 20...

Cancer Relationship Plausibility Formaldehyde
A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats—Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde.
A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats—Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde.

Authors: Campbell Jr, Jerry L., P. Robinan Gentry, Harvey J. Clewell III, and Melvin E. Andersen.
Goal here of this work was to adapt the pharmacokinetic (PK) model for formaldehyde PKs developed for 14C-DNA-protein crosslinks (DPX) and describ...

Cancer Relationship Plausibility Dose Response Threshold Inhalation Exposure Formaldehyde
Peak exposures in epidemiologic studies and cancer risks: considerations for regulatory risk assessment.
Peak exposures in epidemiologic studies and cancer risks: considerations for regulatory risk assessment.

Authors: Checkoway, Harvey, Peter SJ Lees, Linda D. Dell, P. Robinan Gentry, and Kenneth A. Mundt.
Reviews approaches for characterizing "peak" exposures in epidemiologic studies and methods for incorporating peak exposure metrics in dose-respo...

Cancer Relationship Plausibility Formaldehyde
Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA–protein cross-links by liquid chromatography–tandem mass spectrometry.
Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA–protein cross-links by liquid chromatography–tandem mass spectrometry.

Authors: Leng, Jiapeng, Chih-Wei Liu, Hadley J. Hartwell, Rui Yu, Yongquan Lai, Wanda M. Bodnar, Kun Lu, and James A. Swenberg.
In this study, both exogenous and endogenous DNA mono-adduct (N2-HOMe-dG) and DNA–protein crosslinks (dG-Me-Cys) wer...

Cancer Relationship Plausibility Dose Response Threshold Inhalation Exposure Formaldehyde
Commentary on New Formaldehyde Studies in Trp53 Haploinsufficient Mice: Further Support for Nonlinear Risks From Inhaled Formaldehyde.
Commentary on New Formaldehyde Studies in Trp53 Haploinsufficient Mice: Further Support for Nonlinear Risks From Inhaled Formaldehyde.

Author: Thompson, Chad. (2018)
The article discusses the relevance of a 2017 final report by the U. S. National Toxicology Program (NTP) that explored the potential involvement of p53 mutation in formaldehyde-induced nasal tumors and lymphohema...

Cancer Relationship Plausibility Dose Response Threshold Inhalation Exposure Formaldehyde
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